Publications

We review recent advances in surgical methods, labeling strategies, and optical tools that have enabled in vivo, high-resolution imaging of the dynamic behaviors of cells in the spinal cord in mice.

There are two fundamental problems in compressed sensing MRI: (1) where to sample and (2) how to reconstruct. In this paper, we tackle both problems simultaneously, using a novel unsupervised, end-to-end learning framework, called LOUPE.

Probabilistic atlas priors have been commonly used to derive adaptive and robust brain MRI segmentation algorithms. Widely-used neuroimage analysis pipelines rely heavily on these techniques, which are often computationally expensive.

In this paper, we present a probabilistic generative model and derive an unsupervised learning-based inference algorithm that uses insights from classical registration methods and makes use of recent developments in convolutional neural networks.

The ability to manipulate specific neuronal populations of the spinal cord following spinal cord injury (SCI) could prove highly beneficial for rehabilitation in patients through maintaining and strengthening still existing neuronal connections and/or facilitating the formation of new connections.

BioLuminescent (BL) light production can modulate neural activity and behavior through co-expressed OptoGenetic (OG) elements, an approach termed "BL-OG". Yet, the relationship between BL-OG effects and bioluminescent photon emission has not been characterized in vivo.

A fundamental challenge in calcium imaging is to minimize the excitation laser power while still maintaining a sufficient signal-to-noise ratio to distinguish individual transients in the fluorescence traces.

Using mRNA-Seq and de novo transcriptome assembly, we identified, cloned and characterized nine previously undiscovered fluorescent protein (FP) homologs from Aequorea victoria and a related Aequorea species, with most sequences highly divergent from avGFP.

We present a novel remote focusing and demultiplexing scheme that allows simultaneous two- and three-photon imaging of two-layer neural activities, featuring large axial separation, independent foci tunability and large imaging depth enabled by three-photon microscopy.