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Publications
NeuroNex Funded
Meta-learning synaptic plasticity and memory addressing for continual familiarity detection
Neuron
DOI: 10.1016/j.neuron.2021.11.009
Over the course of a lifetime, we process a continual stream of information. Extracted from this stream, memories must be efficiently encoded and stored in an addressable manner for retrieval.
NeuroGen: Activation optimized image synthesis for discovery neuroscience
NeuroImage
DOI: 10.1016/j.neuroimage.2021.118812
Functional MRI (fMRI) is a powerful technique that has allowed us to characterize visual cortex responses to stimuli, yet such experiments are by nature constructed based on a priori hypotheses along with other limitations.
Intravital three-photon microscopy allows visualization over the entire depth of mouse lymph nodes
Nature Immunology
DOI: 10.1038/s41590-021-01101-1
Intravital confocal microscopy and two-photon microscopy are powerful tools to explore the dynamic behavior of immune cells in mouse lymph nodes (LNs), with penetration depth of ~100 and ~300 μm, respectively.
Multiphoton imaging of neural structure and activity in Drosophila through the intact cuticle
eLife
DOI: 10.7554/elife.69094
We developed a multiphoton imaging method to capture neural structure and activity in behaving flies through the intact cuticle. Our measurements showed that the fly head cuticle has surprisingly high transmission at wavelengths >900nm.
Author Correction: A human-specific modifier of cortical connectivity and circuit function
Nature
DOI: 10.1038/s41586-021-04302-8
The cognitive abilities that characterize humans are thought to emerge from unique features of the cortical circuit architecture of the human brain, which include increased cortico–cortical connectivity.
Place cells may simply be memory cells: Memory compression leads to spatial tuning and history dependence
Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.2018422118
The observation of place cells has suggested that the hippocampus plays a special role in encoding spatial information. However, place cell responses are modulated by several nonspatial variables and reported to be rather unstable.
Building an allocentric travelling direction signal via vector computation
Nature
DOI: 10.1038/s41586-021-04067-0
Many behavioural tasks require the manipulation of mathematical vectors, but, outside of computational models1,2,3,4,5,6,7, it is not known how brains perform vector operations.
Flexible filtering by neural inputs supports motion computation across states and stimuli
Current Biology
DOI: 10.1016/j.cub.2021.09.061
Sensory systems flexibly adapt their processing properties across a wide range of environmental and behavioral conditions. Such variable processing complicates attempts to extract a mechanistic understanding of sensory computations.
Olfactory landmarks and path integration converge to form a cognitive spatial map
Neuron
DOI: 10.1016/j.neuron.2021.09.055
The convergence of internal path integration and external sensory landmarks generates a cognitive spatial map in the hippocampus. We studied how localized odor cues are recognized as landmarks by recording the activity of neurons in CA1 during a virtual navigation task.