Publications

Here we use simulations, based on densely-reconstructed electron microscopy microanatomy, with signal structure matched to real barcoding data, to quantify the feasibility of this procedure.

In this review, we discuss the recent literature on neural control of food intake behaviors in mice and flies with the view that these two model organisms complement one another in efforts to uncover conserved principles brains use to regulate energy metabolism and food ingestion.

This manuscript reviews and extends recent work on the mathematical relationship between predictive coding and backpropagation for training feedforward artificial neural networks on supervised learning tasks.

Cortical neurons are characterized by irregular firing and a broad distribution of rates. The balanced state model explains these observations with a cancellation of mean excitatory and inhibitory currents, which makes fluctuations drive firing.

Neuroimaging studies are often limited by the number of subjects and cognitive processes that can be feasibly interrogated. However, a rapidly growing number of neuroscientific studies have collectively accumulated an extensive wealth of results.

A class of models in computational neuroscience that have been successful at describing a variety of effects in the neocortex involve a tight balance between excitatory, inhibitory and unrealistically large external input, without which the model cannot produce robust activity patterns.

Synaptic wiring diagrams, or connectomes, promise constraints for highly detailed neural circuit models, but relating the connectivity information they provide to physiological properties is challenging. A new study describes this relationship for a fruit fly neural pathway.

Intravital confocal microscopy and two-photon microscopy are powerful tools to explore the dynamic behavior of immune cells in mouse lymph nodes (LNs), with penetration depth of ~100 and ~300 μm, respectively.

We developed a multiphoton imaging method to capture neural structure and activity in behaving flies through the intact cuticle. Our measurements showed that the fly head cuticle has surprisingly high transmission at wavelengths >900nm.