Investigation of the long wavelength limit of soliton self-frequency shift in a silica fiber

Optics Express
We explore the long wavelength limit of soliton self-frequency shift in silica-based fibers experimentally and using numerical simulation. We found that the longest wavelength soliton generated by soliton self-frequency shift is approximately 2500 nm.

Three-dimensional intact-tissue sequencing of single-cell transcriptional states

Science
Retrieving high-content gene-expression information while retaining three-dimensional (3D) positional anatomy at cellular resolution has been difficult, limiting integrative understanding of structure and function in complex biological tissues.
preprint

3D Convolutional Neural Networks for Classification of Functional Connectomes

aeXiv
In this work, we propose a novel volumetric Convolutional Neural Network framework that takes advantage of the full-resolution 3D spatial structure of resting-state functional MRI data and fits non-linear predictive models.

Fabrication and characterization of modulation masks for multimodal spatial frequency modulated microscopy

Applied Optics
Spatial frequency modulated imaging (SPIFI) is a powerful imaging method that when used in conjunction with multiphoton contrast mechanisms has the potential to improve the spatial and temporal scales that can be explored within a single nonlinear optical microscope platform.

Fabrication and characterization of modulation masks for multimodal spatial frequency modulated microscopy

Applied Optics
Spatial frequency modulated imaging (SPIFI) is a powerful imaging method that when used in conjunction with multiphoton contrast mechanisms has the potential to improve the spatial and temporal scales that can be explored within a single nonlinear optical microscope platform.

Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy

Biomedical Optics Express
Deep tissue multiphoton imaging requires high peak power to enhance signal and low average power to prevent thermal damage. Both goals can be advantageously achieved through laser repetition rate tuning instead of simply adjusting the average power.
preprint

A Probabilistic Disease Progression Model for Predicting Future Clinical Outcome

arXiv
In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer’s. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory.

Comparison of excitation wavelengths for in vivo deep imaging of mouse brain

SPIE
The attenuation of excitation power reaching the focus is the main issue that limits the depth penetration of highresolution imaging of biological tissue. The attenuation is caused by a combination of tissue scattering and absorption.

In vivo three-photon imaging of deep cerebellum

SPIE
We demonstrate three-photon microscopy (3PM) of mouse cerebellum at 1 mm depth by imaging both blood vessels and neurons. We compared 3PM and 2PM in the mouse cerebellum for imaging green and red fluorescence.