Publications

Interferometric spatial frequency modulation for imaging (I-SPIFI) is demonstrated for the first time, to our knowledge. Significantly, this imaging modality can be seamlessly combined with nonlinear SPIFI imaging and operates through single-element detection.

Neuroscience is experiencing a revolution in which simultaneous recording of thousands of neurons is revealing population dynamics that are not apparent from single-neuron responses. Deeper understanding of this structure requires studying phenomena detected in single trials, which is challenging.

Optical imaging through the intact mouse skull is challenging because of skull-induced aberrations and scattering. We found that three-photon excitation provided improved optical sectioning compared with that obtained with two-photon excitation.

How does attentional modulation of neural activity enhance performance? Here we use a deep convolutional neural network as a large-scale model of the visual system to address this question.

In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer’s. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory.

Traditional deformable registration techniques achieve impressive results and offer a rigorous theoretical treatment, but are computationally intensive since they solve an optimization problem for each image pair.

The naturally occurring channelrhodopsin variant anion channelrhodopsin-1 (ACR1) exhibits large light-gated anion conductance and high anion selectivity when expressed in heterologous settings.

In Bioluminescent Optogenetics a biological, rather than a physical, light source is used to activate light‐sensing opsins, such as channelrhodopsins or pumps. This is commonly achieved by utilizing a luminopsin, a fusion protein of a light‐emitting luciferase tethered to a light‐sensing opsin.

We derive analytic expressions for the three-dimensional coherent transfer function and coherent spread function for coherent holographic image reconstruction by phase transfer microscopy with monochromatic and broadband illumination sources.