Interferometric spatial frequency modulation imaging

Optics Letters
Interferometric spatial frequency modulation for imaging (I-SPIFI) is demonstrated for the first time, to our knowledge. Significantly, this imaging modality can be seamlessly combined with nonlinear SPIFI imaging and operates through single-element detection.

Inferring single-trial neural population dynamics using sequential auto-encoders

Nature Methods
Neuroscience is experiencing a revolution in which simultaneous recording of thousands of neurons is revealing population dynamics that are not apparent from single-neuron responses. Deeper understanding of this structure requires studying phenomena detected in single trials, which is challenging.

Three-photon imaging of mouse brain structure and function through the intact skull

Nature Methods
Optical imaging through the intact mouse skull is challenging because of skull-induced aberrations and scattering. We found that three-photon excitation provided improved optical sectioning compared with that obtained with two-photon excitation.

How biological attention mechanisms improve task performance in a large-scale visual system model

How does attentional modulation of neural activity enhance performance? Here we use a deep convolutional neural network as a large-scale model of the visual system to address this question.

A Bayesian Disease Progression Model for Clinical Trajectories

Graphs in Biomedical Image Analysis and Integrating Medical Imaging and Non-Imaging Modalities
In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer’s. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory.

Unsupervised Learning for Fast Probabilistic Diffeomorphic Registration

Traditional deformable registration techniques achieve impressive results and offer a rigorous theoretical treatment, but are computationally intensive since they solve an optimization problem for each image pair.

Crystal structure of the natural anion- conducting channelrhodopsin GtACR1

The naturally occurring channelrhodopsin variant anion channelrhodopsin-1 (ACR1) exhibits large light-gated anion conductance and high anion selectivity when expressed in heterologous settings.

Defining parameters of specificity for bioluminescent optogenetic activation of neurons using in vitro multi electrode arrays (MEA)

Journal of Neuroscience Research
In Bioluminescent Optogenetics a biological, rather than a physical, light source is used to activate light‐sensing opsins, such as channelrhodopsins or pumps. This is commonly achieved by utilizing a luminopsin, a fusion protein of a light‐emitting luciferase tethered to a light‐sensing opsin.

Three-dimensional single-pixel imaging of incoherent light with spatiotemporally modulated illumination

Journal of the Optical Society of America A
We derive analytic expressions for the three-dimensional coherent transfer function and coherent spread function for coherent holographic image reconstruction by phase transfer microscopy with monochromatic and broadband illumination sources.