POSITIONS HELD
Visiting Assistant Professor and Consultant
Miles Pharmaceuticals, West Haven, CT
Visiting Assistant Professor
The Centers for Genome Research and for Neuroscience, Edinburgh University, UK
Professor of Neuroscience (with tenure)
Brown University
Co-Director
Center for Neurobiology of Cells and Circuits, Brown Institute for Brain Science
Interim Director
Brown Institute for Brain Science
Adjunct Professor
AGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island
Director
Brown Institute for Brain Sciences
AWARDS
2001
NIH K02 Research Career Development Award
2009
Harriet W Sheridan Award for Distinguished Contribution to Teaching at Brown University
2010
Faculty Mentorship Award, Graduate School, Brown University
2013
President’s Award for Excellence in Faculty Governance, Brown University
2013
Dean’s Award for Excellence in Graduate and or Postdoctoral Teaching and Mentoring in the Biological
Education
1986
Ph.D.
University College London
1982
BSc
University College London
1988
Postdoctoral Associate
Yale University of Medicine
1990
Postdoctoral Fellow
Stanford University Medical School
Publications
Long-Term Depression Induced by Optogenetically Driven Nociceptive Inputs to Trigeminal Nucleus Caud
Pradier B, Shin HB, Kim DS, St Laurent R, Lipscombe D, Kauer JA
8/22/2018
Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ chann
Mustafá ER, López Soto EJ, Martínez Damonte V, Rodríguez SS, Lipscombe D, Raingo J
11/15/2017
Cell-Specific RNA Binding Protein Rbfox2 Regulates CaV2.2 mRNA Exon Composition and CaV2.2 Current S
Allen SE, Toro CP, Andrade A, López-Soto EJ, Denome S, Lipscombe D
10/10/2017
Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calci
Tong XJ, López-Soto EJ, Li L, Liu H, Nedelcu D, Lipscombe D, Hu Z, Kaplan JM
7/19/2017
Lipscombe D, Andrade A
5/23/2017
Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spina
O'Hern PJ, do Carmo G Gonçalves I, Brecht J, López Soto EJ, Simon J, Chapkis N, Lipscombe D, Kye MJ,
5/2/2017
Andrade A, Hope J, Allen A, Yorgan V, Lipscombe D, Pan JQ
10/19/2016
Groen JL, Andrade A, Ritz K, Jalalzadeh H, Haagmans M, Bradley TE, Jongejan A, Verbeek DS, Nürnberg
2/15/2015
Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of vo
Jiang YQ, Andrade A, Lipscombe D
12/26/2013
Lipscombe D, Allen SE, Toro CP
7/30/2013
Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral conse
Lipscombe D, Andrade A, Allen SE
9/26/2012
Marangoudakis S, Andrade A, Helton TD, Denome S, Castiglioni AJ, Lipscombe D
7/25/2012
The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium ch
Allen SE, Darnell RB, Lipscombe D
12/31/2010
Andrade A, Denome S, Jiang YQ, Marangoudakis S, Lipscombe D
9/19/2010
The alpha(2)delta subunit augments functional expression and modifies the pharmacology of Ca(V)1.3 L
Andrade A, Sandoval A, González-Ramírez R, Lipscombe D, Campbell KP, Felix R
9/30/2009
The inhibition of neuronal calcium ion channels by trace levels of yttrium released from carbon nano
Jakubek LM, Marangoudakis S, Raingo J, Liu X, Lipscombe D, Hurt RH
8/20/2009
Richards KS, Swensen AM, Lipscombe D, Bommert K
11/13/2007
Lipscombe D, Raingo J
7/27/2007
Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Li
6/13/2007
Gray AC, Raingo J, Lipscombe D
5/18/2007
Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nocicepto
Raingo J, Castiglioni AJ, Lipscombe D
2/11/2007
Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium ch
Castiglioni AJ, Raingo J, Lipscombe D
10/1/2006
Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding d
Wyllie DJ, Johnston AR, Lipscombe D, Chen PE
7/15/2006
Helton TD, Xu W, Lipscombe D
11/2/2005
Alternative splicing in the voltage-sensing region of N-Type CaV2.2 channels modulates channel kinet
Lin Y, McDonough SI, Lipscombe D
6/16/2004
Thaler C, Gray AC, Lipscombe D
4/1/2004
Bell TJ, Thaler C, Castiglioni AJ, Helton TD, Lipscombe D
1/8/2004
Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alph
Lipscombe D, Pan JQ, Gray AC
8/1/2002
Xu W, Lipscombe D
8/15/2001
Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: funct
Pan JQ, Lipscombe D
7/1/2000
Schorge S, Gupta S, Lin Z, McEnery MW, Lipscombe D
9/2/1999
Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calc
Lin Z, Lin Y, Schorge S, Pan JQ, Beierlein M, Lipscombe D
7/1/1999
Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic gangl
Lin Z, Haus S, Edgerton J, Lipscombe D
1/1/1997
Lin Z, Harris C, Lipscombe D
12/1/1996
Delcour AH, Lipscombe D, Tsien RW
1/1/1993
Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type
Lipscombe D, Kongsamut S, Tsien RW
8/24/1989
The N-type Ca channel in frog sympathetic neurons and its role in alpha-adrenergic modulation of tra
Kongsamut S, Lipscombe D, Tsien RW
6/1/1989
Tsien RW, Lipscombe D, Madison DV, Bley KR, Fox AP
10/1/1988
Lipscombe D, Rang HP
9/1/1988
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neuro
Lipscombe D, Madison DV, Poenie M, Reuter H, Tsien RW, Tsien RY
7/1/1988
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell b
Lipscombe D, Madison DV, Poenie M, Reuter H, Tsien RY, Tsien RW
4/1/1988
I graduated with a PhD in Pharmacology from University College London in 1986 and then studied with Richard W Tsien as a postdoctoral associate at Yale University School of Medicine and subsequently at Stanford University Medical School. In 1992 I joined the Department of Neuroscience at Brown. I study the expression, regulation, and function of voltage-gated calcium ion channels in different regions of the nervous system. I am also interested in their role in chronic pain and psychiatric disorders. I work closely with undergraduate and graduate students, as well as postdoctoral trainees. I direct the Brown Institute for Brain Science and Direct NIH funded Predoctoral Training Programs in Neuroscience.
