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Diane Lipscombe
ORCID 0000-0002-7146-9119
Website
POSITIONS HELD
Director
Brown Institute for Brain Sciences
Adjunct Professor
AGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island
Co-Director
Center for Neurobiology of Cells and Circuits, Brown Institute for Brain Science
Visiting Assistant Professor and Consultant
Miles Pharmaceuticals, West Haven, CT
Interim Director
Brown Institute for Brain Science
Visiting Assistant Professor
The Centers for Genome Research and for Neuroscience, Edinburgh University, UK
Professor of Neuroscience (with tenure)
Brown University
AWARDS
2013
Dean’s Award for Excellence in Graduate and or Postdoctoral Teaching and Mentoring in the Biological
2013
President’s Award for Excellence in Faculty Governance, Brown University
2010
Faculty Mentorship Award, Graduate School, Brown University
2009
Harriet W Sheridan Award for Distinguished Contribution to Teaching at Brown University
2001
NIH K02 Research Career Development Award
EDUCATION
1/1/1990
Postdoctoral Fellow
Stanford University Medical School
1/1/1988
Postdoctoral Associate
Yale University of Medicine
1/1/1986
Ph.D.
University College London
1/1/1982
BSc
University College London
Publications
Bruno Pradier, Hye Bin Shin, Duk Soo Kim, Robyn St. Laurent, Diane Lipscombe, Julie A. Kauer
Long-Term Depression Induced by Optogenetically Driven Nociceptive Inputs to Trigeminal Nucleus Caudalis or Headache Triggers
The Journal of Neuroscience 38 (2018)
Diane Lipscombe, Eduardo Javier Lopez-Soto
Protected by a Fox
Neuron 98 (2018)
Summer E. Allen, Cecilia P. Toro, Arturo Andrade, Eduardo J. López-Soto, Sylvia Denome, Diane Lipscombe
Cell-Specific RNA Binding Protein Rbfox2 Regulates CaV2.2 mRNA Exon Composition and CaV2.2 Current Size
eneuro 4 (2017)
Xia-Jing Tong, Eduardo Javier López-Soto, Lei Li, Haowen Liu, Daniel Nedelcu, Diane Lipscombe, Zhitao Hu, Joshua M. Kaplan
Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels
Neuron 95 (2017)
Calcium Channel CaVα₁ Splice Isoforms - Tissue Specificity and Drug Action
(2017)
Patrick J O'Hern, Inês do Carmo G. Gonçalves, Johanna Brecht, Eduardo Javier López Soto, Jonah Simon, Natalie Chapkis, Diane Lipscombe, Min Jeong Kye, Anne C Hart
Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models
eLife 6 (2017)
Emilio R. Mustafá, Eduardo J. López Soto, Valentina Martínez Damonte, Silvia S. Rodríguez, Diane Lipscombe, Jesica Raingo
Ghrelin receptor constitutive activity reduces surface expression of voltage-gated calcium channels in a CaVβ dependent manner
Journal of Cell Science (2017)
A. Andrade, J. Hope, A. Allen, V. Yorgan, D. Lipscombe, J. Q. Pan
A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity
Scientific Reports 6 (2016)
Diane Lipscombe, Jen Q. Pan, Stephanie Schorge
Tracks through the genome to physiological events
Experimental Physiology 100 (2015)
J. L. Groen, A. Andrade, K. Ritz, H. Jalalzadeh, M. Haagmans, T. E. J. Bradley, A. Jongejan, D. S. Verbeek, P. Nurnberg, S. Denome, R. C. M. Hennekam, D. Lipscombe, F. Baas, M. A. J. Tijssen
CACNA1B mutation is linked to unique myoclonus-dystonia syndrome
Human Molecular Genetics 24 (2014)
Diane Lipscombe, Summer E. Allen, Cecilia P. Toro
Control of neuronal voltage-gated calcium ion channels from RNA to protein
Trends in Neurosciences 36 (2013)
Diane Lipscombe, Arturo Andrade, Summer E. Allen
Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences
Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (2013)
Yu-Qiu Jiang, Arturo Andrade, Diane Lipscombe
Spinal Morphine but not Ziconotide or Gabapentin Analgesia is Affected by Alternative Splicing of Voltage-Gated Calcium Channel Cav2.2 Pre-mRNA
Molecular Pain 9 (2013)
S. Marangoudakis, A. Andrade, T. D. Helton, S. Denome, A. J. Castiglioni, D. Lipscombe
Differential Ubiquitination and Proteasome Regulation of CaV2.2 N-Type Channel Splice Isoforms
Journal of Neuroscience 32 (2012)
Summer E. Allen, Robert B. Darnell, Diane Lipscombe
The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels
Channels 4 (2010)
Arturo Andrade, Sylvia Denome, Yu-Qiu Jiang, Spiro Marangoudakis, Diane Lipscombe
Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing
Nature Neuroscience 13 (2010)
Arturo Andrade, Alejandro Sandoval, Ricardo González-Ramírez, Diane Lipscombe, Kevin P. Campbell, Ricardo Felix
The α2δ subunit augments functional expression and modifies the pharmacology of CaV1.3 L-type channels
Cell Calcium 46 (2009)
Lorin M. Jakubek, Spiro Marangoudakis, Jesica Raingo, Xinyuan Liu, Diane Lipscombe, Robert H. Hurt
The inhibition of neuronal calcium ion channels by trace levels of yttrium released from carbon nanotubes
Biomaterials 30 (2009)
Diane Lipscombe, Jennifer Qian Pan
Tripping the HCN Breaker
Neuron 62 (2009)
Will Fairbrother, Diane Lipscombe
Repressing the neuron within
BioEssays 30 (2007)
Kathryn S. Richards, Andrew M. Swensen, Diane Lipscombe, Kurt Bommert
Novel CaV2.1 clone replicates many properties of Purkinje cell CaV2.1 current
European Journal of Neuroscience 26 (2007)
A GRAY, J RAINGO, D LIPSCOMBE
Neuronal calcium channels: Splicing for optimal performance
Cell Calcium 42 (2007)
Diane Lipscombe, Jesica Raingo
Alternative Splicing Matters: N-Type Calcium Channels in Nociceptors
Channels 1 (2007)
C. Altier, C. S. Dale, A. E. Kisilevsky, K. Chapman, A. J. Castiglioni, E. A. Matthews, R. M. Evans, A. H. Dickenson, D. Lipscombe, N. Vergnolle, G. W. Zamponi
Differential Role of N-Type Calcium Channel Splice Isoforms in Pain
Journal of Neuroscience 27 (2007)
Jesica Raingo, Andrew J Castiglioni, Diane Lipscombe
Alternative splicing controls G protein–dependent inhibition of N-type calcium channels in nociceptors
Nature Neuroscience 10 (2007)
Andrew J. Castiglioni, Jesica Raingo, Diane Lipscombe
Alternative splicing in the C‐terminus of CaV2.2 controls expression and gating of N‐type calcium channels
The Journal of Physiology 576 (2006)
David J. A. Wyllie, Alexander R. Johnston, Diane Lipscombe, Philip E. Chen
Single‐channel analysis of a point mutation of a conserved serine residue in the S2 ligand‐binding domain of the NR2A NMDA receptor subunit
The Journal of Physiology 574 (2006)
Diane Lipscombe, Jesica Raingo
Internalizing channels: a mechanism to control pain?
Nature Neuroscience 9 (2006)
Thomas D. Helton, Weifeng Xu, Diane Lipscombe
Neuronal L-Type Calcium Channels Open Quickly and Are Inhibited Slowly
The Journal of Neuroscience 25 (2005)
Diane Lipscombe
Neuronal proteins custom designed by alternative splicing
Current Opinion in Neurobiology 15 (2005)
Yingxin Lin, Stefan I. McDonough, Diane Lipscombe
Alternative Splicing in the Voltage-Sensing Region of N-Type CaV2.2 Channels Modulates Channel Kinetics
Journal of Neurophysiology 92 (2004)
Diane Lipscombe, Thomas D. Helton, Weifeng Xu
L-Type Calcium Channels: The Low Down
Journal of Neurophysiology 92 (2004)
Christopher Thaler, Annette C. Gray, Diane Lipscombe
Cumulative inactivation of N-type CaV2.2 calcium channels modified by alternative splicing
Proceedings of the National Academy of Sciences 101 (2004)
Thomas J Bell, Christopher Thaler, Andrew J Castiglioni, Thomas D Helton, Diane Lipscombe
Cell-Specific Alternative Splicing Increases Calcium Channel Current Density in the Pain Pathway
Neuron 41 (2004)
Diane Lipscombe
L-Type Calcium Channels
Circulation Research 90 (2002)
Diane Lipscombe, Jennifer Qian Pan, Annette C Gray
Functional Diversity in Neuronal Voltage-Gated Calcium Channels by Alternative Splicing of Ca<sub>v</sub>α<sub>1</sub>
Molecular Neurobiology 26 (2002)
Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials
(2001)
Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: funct
(2000)
Stephanie Schorge, Seema Gupta, Zhixin Lin, Maureen W. McEnery, Diane Lipscombe
Calcium channel activation stabilizes a neuronal calcium channel mRNA
Nature Neuroscience 2 (1999)
Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calc
(1999)
Zhixin Lin, Stephanie Haus, Jeremy Edgerton, Diane Lipscombe
Identification of Functionally Distinct Isoforms of the N-Type Ca2+ Channel in Rat Sympathetic Ganglia and Brain
Neuron 18 (1997)
Zhixin Lin, Charles Harris, Diane Lipscombe
The molecular identity of Ca channel α1-subunits expressed in rat sympathetic neurons
Journal of Molecular Neuroscience 7 (1996)
Reflections on Ca(2+)-channel diversity
(1995)
Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics
(1993)
Diane Lipscombe, Sathapana Kongsamut, Richard W. Tsien
α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating
Nature 340 (1989)
SATHAPANA KONGSAMUT, DIANE LIPSCOMBE, RICHARD W. TSIEN
The N‐Type Ca Channel in Frog Sympathetic Neurons and Its Role in α‐Adrenergic Modulation of Transmitter Release
Annals of the New York Academy of Sciences 560 (1989)
Nicotinic receptors of frog ganglia resemble pharmacologically those of skeletal muscle
(1988)
Diane Lipscombe, Daniel V. Madison, Martin Poenie, Harald Reuter, Richard W. Tsien, Roger Y. Tsien
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons
Neuron 1 (1988)
D Lipscombe, D V Madison, M Poenie, H Reuter, R Y Tsien, R W Tsien
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
Proceedings of the National Academy of Sciences 85 (1988)
R.W. Tsien, D. Lipscombe, D.V. Madison, K.R. Bley, A.P. Fox
Multiple types of neuronal calcium channels and their selective modulation
Trends in Neurosciences 11 (1988)
I graduated with a PhD in Pharmacology from University College London in 1986 and then studied with Richard W Tsien as a postdoctoral associate at Yale University School of Medicine and subsequently at Stanford University Medical School. In 1992 I joined the Department of Neuroscience at Brown. I study the expression, regulation, and function of voltage-gated calcium ion channels in different regions of the nervous system. I am also interested in their role in chronic pain and psychiatric disorders. I work closely with undergraduate and graduate students, as well as postdoctoral trainees. I direct the Brown Institute for Brain Science and Direct NIH funded Predoctoral Training Programs in Neuroscience.